Frequency of cutaneous drug reactions in the outpatient dermatology clinic at the National Institute of Cardiology Ignacio Chávez over a ten-year period

Silvia Coria-Vázquez, Universidad Del Valle de México Campus Querétaro, Querétaro, Qro., México
Samantha Cruz-López, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México
Katya Espino-Mier, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México
Sonia M. Lara-Morales, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México
María F. Suárez-Velázquez, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México
Rosa Ma. Lacy-Niebla, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México

Cutaneous adverse drug reactions, or pharmacodermias, are the most common form of adverse drug reactions (ADR). It was our interest to know their epidemiological behavior in a tertiary hospital level in Mexico. We stablished the frequency of ADR in 61 infants and adults hospitalized patients and those seen in the outpatient Dermatology Clinic at the National Institute of Cardiology Ignacio Chávez in Mexico City (INCICh) over a period of 10 years. The most frequently diagnosed pharmacodermias were acneiform dermatitis, cutaneous hyperpigmentation and maculopapular exanthema mainly associated to prednisone, hydroxychloroquine, cephalothin, amiodarone and vitamin B-complex, although we registered less frequently more severe and hazardous reactions. These results were consistent with other reports in our country. Multiple drugs administered at a time was an important causative factor for the ADR. It is necessary for every practitioner to develop skills that permit the Fármacos. Reacción adversa a medicamentos. Reacción adversa cutánea a medicamentos. Farmacodermia.

Keywords: Drugs. Adverse drug reaction. Cutaneous adverse drug reaction. Pharmacodermia.