Clinical characterization of patients with cardiac amyloidosis in a referral center of Colombia

Paola Ortiz, Department of Heart Failure, Fundación Cardioinfantil-La Cardio, Bogotá, Colombia
Camilo A. Polania-Sandoval, Vascular and Endovascular Surgery Investigation Group, Fundación Cardioinfantil-La Cardio, Bogotá, Colombia
Juliana Gaviria-Villegas, Vascular and Endovascular Surgery Investigation Group, Fundación Cardioinfantil-La Cardio, Bogotá, Colombia
Claudia Gutiérrez-Villamil, Department of Nuclear Medicine, Fundación Cardioinfantil-La Cardio, Bogotá, Colombia
Clarena Zuluaga-Arbeláez, Department of Nuclear Medicine, Fundación Cardioinfantil-La Cardio, Bogotá, Colombia
Víctor Marin-Oyaga, Department of Nuclear Medicine, Fundación Cardioinfantil-La Cardio, Bogotá, Colombia
M.J. Rodríguez-González, Department of Heart Failure, Fundación Cardioinfantil-La Cardio, Bogotá, Colombia

Objective: The objective of the study is to describe the characteristics of our first cohort of amyloidosis in a Latin America cardiovascular reference center in Colombia. Methods: This is a historic cohort study and data were taken from the electronic records of the Fundación Cardioinfantil-Instituto de cardiología; adult patients with a diagnosis of cardiac amyloidosis were included and a descriptive analysis was presented. Results: A total of 31 patients with amyloidosis were included. 17 were Transthyretin Amyloidosis (ATTR) subtype and 14 were AL subtype. An overall mortality of 25% was found. The mean age at diagnosis was 74 years, male sex predominant. More frequent comorbidities were hypertension and atrial fibrillation. The most frequent clinical presentation was congestive heart failure (75%), with mildly reduced ejection fraction (41.94%), followed by reduced ejection fraction (32.26%), and preserved ejection fraction (25.81%). In the ATTR subtype, a reduced ejection fraction was found at 41.18% and a mildly reduced ejection fraction at 35.29%. Conclusion: These results provide information on the most frequent type of amyloidosis and the late timing to diagnose in our historic cohort study, we present some of the baseline characteristics and most frequent approaches to diagnose Cardiac Amyloidosis that represents all challenges in clinical practice. Improvements are needed in the diagnosis and early treatment of these patients.

Keywords: AL amyloidosis. Amyloidosis. Heart failure. Transthyretin amyloidosis.