Factors associated with left ventricular diastolic dysfunction in adults from a region of the Andes in Peru

Aníbal V. Díaz-Lazo, Facultad de Medicina Humana, Universidad Peruana Los Andes, Huancayo; Hospital Regional Docente Clínico Quirúrgico Daniel Alcides Carrión, Huancayo; Perú
Mely Ruiz-Aquino, Universidad de Huánuco, Huánuco, Perú
Hugo Arroyo-Hernández, Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma, Lima. Perú

Objective: To determine the factors associated with left ventricular diastolic dysfunction (LVDD) in adults residing in a region of the Andes in Peru. Method: A case-control study was conducted on adults living at an altitude of more than 3000 meters in Peru. Cases consisted of patients diagnosed with LVDD through echocardiography, whereas controls were adults without LVDD, as confirmed by echocardiography. Results: A total of 50 cases and 100 controls were included in the study. Among them, 38.7% had high blood pressure, and 41.3% were overweight. Upon adjusted analysis, age 60 or older (aOR: 4.06; 95%CI: 1.29-12.8), female sex (aOR: 2.24; 95%CI: 1.01-4.96) and left ventricular hypertrophy (aOR: 3.17; 95%CI: 1.41-7.17) were identified as statistically significant factors associated with LVDD. Conclusions: The risk of LVDD is associated with older adults, female gender, and left ventricular hypertrophy among individuals residing above 3000 meters altitude in a region of the Andes, in Peru.

Keywords: Risk factors. Ventricular dysfunction. Left ventricular hypertrophy. Heart diseases.